Nef ligand-2
Nef ligand-2 is a binder of Nef. Nef ligand-2 is Ligands for E3 Ligase. Nef ligand-2 is the Nef Binder portion of FC-14369 (HY-171860) [1].
Product Specifications
CAS Number
[3066896-28-1]
UNSPSC
12352005
Target
HIV; Ligands for E3 Ligase
Related Pathways
Anti-infection; PROTAC
Field of Research
Infection
Smiles
O=C(COC1=CC=C(CCC2=C(O)N(C3=NC4=C(N3)C=C(Cl)C=C4)N=C2C5=CC=C(C(F)(F)F)C=C5)C=C1)O
Molecular Formula
C27H20ClF3N4O4
Molecular Weight
556.92
References & Citations
[1]Emert-Sedlak LA, et al. PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication. Cell Chem Biol. 2024 Apr 18;31 (4) :658-668.e14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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