FC-14369

FC-14369 is a PROTAC degrader targeting HIV-1 Nef protein with a DC50 value of 160 nM. FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase via its bifunctional structure, inducing Nef ubiquitination and proteasomal degradation to restore cell-surface CD4 and MHC-I expression and inhibit HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS[1]. (Pink: Nef ligand-2 (HY-171862) ; Black: Ethylenediamine (HY-Y0275) ; Blue: Thalidomide (HY-14658) )

Product Specifications

CAS Number

[3066894-28-5]

UNSPSC

12352005

Target

HIV; PROTACs

Related Pathways

Anti-infection; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

97.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCNC(COC4=CC=C(CCC5=C(O)N(C6=NC7=C(N6)C=CC(Cl)=C7)N=C5C8=CC=C(C(F)(F)F)C=C8)C=C4)=O)=CC=C3)=O)=O

Molecular Formula

C42H34ClF3N8O7

Molecular Weight

855.22

References & Citations

[1]Emert-Sedlak LA, et al. PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication. Cell Chem Biol. 2024 Apr 18;31 (4) :658-668.e14.