FC-14367
FC-14367 is a PROTAC degrader targeting HIV-1 Nef protein. FC-14367 forms a ternary complex by binding Nef and Cereblon E3 ubiquitin ligase, inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS[1]. (Black: Glycolic acid ; Blue: 2- (2,6-Dioxopiperidin-3-yl) phthalimidine (HY-138793) )
Product Specifications
CAS Number
3066893-65-7
UNSPSC
12352005
Target
HIV; PROTACs
Related Pathways
Anti-infection; PROTAC
Field of Research
Cancer
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2)C(OCC(N4CCC(CC4)C5=NN(C6=NC7=C(N6)C=CC(Cl)=C7)C(O)=C5CCC8=CC=C(C=C8)F)=O)=CC=C3)=O)=O
Molecular Formula
C38H35ClFN7O6
Molecular Weight
740.18
References & Citations
[1]Emert-Sedlak LA, et al. PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication. Cell Chem Biol. 2024 Apr 18;31 (4) :658-668.e14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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