SB-583355
SB-583355 (Compound 56) is a potent G2A antagonist. SB-583355 can be prepared by a Suzuki reaction between 4-methoxyphenyl boronic acid and 3-bromo-4-hydroxybenzoic acid following the conditions followed by an amide coupling reaction. SB-583355 blocks the activation of G2A mediated either by 9-HOPE or T-10148 in human G2A expressing CHO-K1 cells. SB-583355 can be studied in research for inflammation, myeloid leukemia, and neuropathic pain[1].
Product Specifications
CAS Number
[3040121-49-8]
UNSPSC
12352005
Target
G2A (GPR132)
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
OC1=CC=C(C(N[C@H](C(NC2CCCCC2)=O)CC3=CC=CC=C3)=O)C=C1C4=CC=C(C=C4)OC
Molecular Formula
C29H32N2O4
Molecular Weight
472.58
References & Citations
[1]Victor Hernandez-Olmo, et al., Development of a Potent and Selective G2A (GPR132) Agonist. J. Med. Chem. 2024, 67, 13, 10567–10588.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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