LY3526318
LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM) . LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis[1][2].
Product Specifications
CAS Number
1889218-34-1
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.92
Solubility
DMSO : 80 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=NC=C(C=N1)C2=NC(NC([C@@H](N3C4=C(N=C3)N(C(N(C4=O)CC5=NC(C)=NO5)=O)C)C)=O)=CC=C2
Molecular Formula
C23H19F3N10O4
Molecular Weight
556.46
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPA1
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Cytokeratin 1 (Suprabasal Keratinocyte Marker) (LHK1), CF640R conjugate, 0.1mg/mL
