LY3526318
LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM) . LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis[1][2].
Product Specifications
CAS Number
1889218-34-1
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.92
Solubility
DMSO : 80 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=NC=C(C=N1)C2=NC(NC([C@@H](N3C4=C(N=C3)N(C(N(C4=O)CC5=NC(C)=NO5)=O)C)C)=O)=CC=C2
Molecular Formula
C23H19F3N10O4
Molecular Weight
556.46
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPA1
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Colloidal Gold Conjugated Rabbit Affinity Purified Antibody to Laminin (Mouse EHS Sarcoma), 10nm
Tapasin Related Protein (TAPBPL) Human Gene Knockout Kit (CRISPR)
