DPC 684

DPC 684 is a potent and selective HIV-1 protease inhibitor (IC90 = 5.7-40 nM, Ki = 0.021 nM) . DPC 684 competitively inhibits HIV-1 protease and blocks viral polyprotein cleavage. DPC 684 has low protein binding and broad-spectrum inhibition against a variety of wild-type and mutant HIV-1 proteases. DPC 684 has low protein binding and broad-spectrum inhibition (IC90 = 1.9-6.3 nM) . DPC 684 has research significance for HIV[1].

Product Specifications

CAS Number

[284661-73-0]

UNSPSC

12352005

Target

HIV; HIV Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=S(N(CC(C)C)C[C@@H](O)[C@@H](NC([C@H](C(C)(C)C)NC(CNCC1=CC(F)=CC=C1)=O)=O)CC2=CC=CC=C2)(C3=CC=C(C=C3)N)=O

Molecular Formula

C35H48FN5O5S

Molecular Weight

669.85

References & Citations

[1]R F Kaltenbach 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45 (11) :3021-8.