DPC 684
DPC 684 is a potent and selective HIV-1 protease inhibitor (IC90 = 5.7-40 nM, Ki = 0.021 nM) . DPC 684 competitively inhibits HIV-1 protease and blocks viral polyprotein cleavage. DPC 684 has low protein binding and broad-spectrum inhibition against a variety of wild-type and mutant HIV-1 proteases. DPC 684 has low protein binding and broad-spectrum inhibition (IC90 = 1.9-6.3 nM) . DPC 684 has research significance for HIV[1].
Product Specifications
CAS Number
284661-73-0
UNSPSC
12352005
Target
HIV; HIV Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=S(N(CC(C)C)C[C@@H](O)[C@@H](NC([C@H](C(C)(C)C)NC(CNCC1=CC(F)=CC=C1)=O)=O)CC2=CC=CC=C2)(C3=CC=C(C=C3)N)=O
Molecular Formula
C35H48FN5O5S
Molecular Weight
669.85
References & Citations
[1]R F Kaltenbach 3rd, et al. DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45 (11) :3021-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940218-100 1x 100 µL
CD100 (Semaphorin-4D) (A8), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470806-100 1x 100 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040181-500 1x 500 µL
CD59 (heavy chain of Protectin) (BRA-10G), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 