MS105
MS105 (YX39-105) is an orally active and selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. MS105 recruits VHL E3 ligase via the VHL ligand moiety to promote PTK6 ubiquitination and proteasomal degradation, inhibiting breast cancer cell proliferation, migration, and inducing apoptosis. MS105 is promising for research of breast cancer. (Pink: BRK inhibitor P21d hydrochloride ; Black: linker (HY-W105727) ; Blue: (S, R, S) -AHPC (HY-125845) )[2].
Product Specifications
CAS Number
2408339-39-7
Product Name Alternative
YX39-105
UNSPSC
12352005
Target
Apoptosis; PROTACs; Tyrosinase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C([C@H]1N(C([C@@H](NC(CCCCCCCCNC(CN2CCN(C(C3=CC=C(NC4=NC(C5CC5)=CN6C4=NC=C6C7=CNN=C7)C(F)=C3)=O)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8
Molecular Formula
C56H70FN13O6S
Molecular Weight
1072.30
References & Citations
[1]Martinez C, et al. A PROTAC degrader suppresses oncogenic functions of PTK6, inducing apoptosis of breast cancer cells. Cell Chem Biol. 2025 Feb 20;32 (2) :255-266.e8.|[2]Jian Jin, et al. Protein tyrosine kinase 6 (ptk6) degradation / disruption compounds and methods of use. WO2020010204A1. 2020-01-09.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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