MS105

MS105 (YX39-105) is an orally active and selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. MS105 recruits VHL E3 ligase via the VHL ligand moiety to promote PTK6 ubiquitination and proteasomal degradation, inhibiting breast cancer cell proliferation, migration, and inducing apoptosis. MS105 is promising for research of breast cancer. (Pink: BRK inhibitor P21d hydrochloride (HY-115514) ; Black: linker (HY-W105727) ; Blue: (S, R, S) -AHPC (HY-125845) ) [1][2].

Product Specifications

CAS Number

[2408339-39-7]

Product Name Alternative

YX39-105

UNSPSC

12352005

Target

Apoptosis; PROTACs; Tyrosinase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C([C@H]1N(C([C@@H](NC(CCCCCCCCNC(CN2CCN(C(C3=CC=C(NC4=NC(C5CC5)=CN6C4=NC=C6C7=CNN=C7)C(F)=C3)=O)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8

Molecular Formula

C56H70FN13O6S

Molecular Weight

1072.30

References & Citations

[1]Martinez C, et al. A PROTAC degrader suppresses oncogenic functions of PTK6, inducing apoptosis of breast cancer cells. Cell Chem Biol. 2025 Feb 20;32 (2) :255-266.e8.|[2]Jian Jin, et al. Protein tyrosine kinase 6 (ptk6) degradation / disruption compounds and methods of use. WO2020010204A1. 2020-01-09.