SIAIS001

SIAIS001 is a potent and orally active PROTAC ALK degrader with a DC50 of 3.9 nM. SIAIS001 induces G1/S phase cell cycle arrest and inhibits proliferation of SR cells (IC50 = 0.9 nM) . SIAIS001 can be used for non-small cell lung cancer (NSCLC) and anaplastic large-cell lymphomas (ALCLs) research[1].

Product Specifications

CAS Number

[2570251-63-5]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; PROTACs

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

N#CC1=CC(NC2=C3C(C4=C(C2(C)C)C=C(N5CCC(CC5)N6CCN(CCCC#CC7=CC=CC8=C7CN(C9C(NC(CC9)=O)=O)C8=O)CC6)C(CC)=C4)=O)=C3C=C1

Molecular Formula

C48H51N7O4

Molecular Weight

789.96

References & Citations

[1]Ren C, et al. Structure-based discovery of SIAIS001 as an oral bioavailability ALK degrader constructed from Alectinib. Eur J Med Chem. 2021 May 5;217:113335.