Cys-MC-VC-PAB-MMAE
Cys-MC-VC-PAB-MMAE consists a cleavable ADC linker (Cys-MC-VC-PAB) and a potent tubulin inhibitor (MMAE) . Cys-MC-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
3051855-32-1
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Microtubule/Tubulin
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.23
Solubility
DMSO : 100 mg/mL
Smiles
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C(CC4=O)SC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
Molecular Formula
C71H112N12O17S
Molecular Weight
1437.78
References & Citations
[1]Krzyscik MA, et al. Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model. Biomacromolecules. 2021 Oct 11;22 (10) :4169-4180.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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