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Cys-MC-VC-PAB-MMAE

Cys-MC-VC-PAB-MMAE consists a cleavable ADC linker (Cys-MC-VC-PAB) and a potent tubulin inhibitor (MMAE) . Cys-MC-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

3051855-32-1

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Microtubule/Tubulin

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.23

Solubility

DMSO : 100 mg/mL

Smiles

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C(CC4=O)SC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O

Molecular Formula

C71H112N12O17S

Molecular Weight

1437.78

References & Citations

[1]Krzyscik MA, et al. Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model. Biomacromolecules. 2021 Oct 11;22 (10) :4169-4180.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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