BMS-986497

BMS-986497 (ORM-6151) is a CD33-targeted antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells, inducing GSPT1 protein degradation. BMS-986497 is promising for research of acute myeloid leukemia (AML) [1][2].

Product Specifications

Product Name Alternative

ORM-6151

UNSPSC

12352211

Target

Transmembrane Glycoprotein

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[BMS-986497]

References & Citations

[1]Li X, et al. Myelodysplastic Neoplasms (MDS) : Pathogenesis and Therapeutic Prospects[J]. Biomolecules, 2025, 15 (6) : 761.|[2]Palacino J, et al. ORM-6151: a first-in-class CD33-antibody enabled GSPT1 degrader for AML[J]. Cancer Research, 2023, 83 (7_Supplement) : 2700-2700.