CHK1-IN-12
CHK1-IN-12 (Compound example 1-5) is an orally active and highly selective checkpoint kinase 1 (CHK1) inhibitor with in vitro enzyme IC50≤10 nM and cellular IC50≤50 nM. CHK1-IN-12 inhibits the phosphorylation activity of CHK1 kinase to block the DNA damage response pathway, inducing tumor cell cycle arrest and apoptosis. CHK1-IN-12 is promising for research of cancers[1].
Product Specifications
CAS Number
[2871056-82-3]
UNSPSC
12352005
Target
Apoptosis; Checkpoint Kinase (Chk)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=CC=CC(O[C@@H]2C[C@H](C2)N)=C1C3=CC(NC4=NC=C(C#N)N=C4)=NN3
Molecular Formula
C19H19N7O2
Molecular Weight
377.40
References & Citations
[1]Anthony B. Pinkerton, et al. Checkpoint kinase 1 (chk1) inhibitors and uses thereof. WO2022251502A1. 2022-12-01.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1
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