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Erufosine

Erufosine is an inhibitor of PI3K/Akt and Ras/Raf/MAPK signaling pathways. Erufosine inhibits the activity of breast cancer cell lines MCF-7 and MDA-MB 231 (IC50: 40.95/40.8 μM) . Erufosine reduces the phosphorylation of PI3K (p85), Akt (PKB), and cRaf. Erufosine can be used in the study of breast cancer and myeloid leukemia[1].

Product Specifications

CAS Number

202867-33-2

Product Name Alternative

ErPC3; Erucylphosphohomocholine

UNSPSC

12352128

Target

Akt; p38 MAPK; PI3K; Raf; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CCCCCCCC/C=C\CCCCCCCCCCCCOP(OCCC[N+](C)(C)C)([O-])=O

Molecular Formula

C28H58NO4P

Molecular Weight

503.74

References & Citations

[1]Dineva IK, et al. Erufosine suppresses breast cancer in vitro and in vivo for its activity on PI3K, c-Raf and Akt proteins. J Cancer Res Clin Oncol. 2012 Nov;138 (11) :1909-17.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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