OPB-3206

OPB-3206 is a selective matrix metalloproteinase (MMP) inhibitor. OPB-3206 inhibits interstitial collagenase, gelatinase A (MMP-2), gelatinase B (MMP-9) and stromelysin with IC50 values of 7x10-7 M, 5x10-6 M, 5x10-7 M and 2x10-6 M, respectively. OPB-3206 reversibly binds to the zinc-binding region of MMPs, preventing the activation of MMP-9 and reducing extracellular matrix degradation to inhibit tumor lung metastasis. OPB-3206 is promising for research of lung metastasis of osteosarcoma[1].

Product Specifications

CAS Number

[166245-54-1]

UNSPSC

12352005

Target

MMP

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CON1C2=CC=CC=C2C[C@@H](C1=O)NC([C@H](CC(C)C)CC(NO)=O)=O

Molecular Formula

C18H25N3O5

Molecular Weight

363.41

References & Citations

[1]Kido A, et al. Inhibition of Spontaneous Rat Osteosarcoma Lung Metastasis by 3S‐[4‐ (Nhydroxyamino) ‐2R‐isobutylsuccinyl] amino‐1‐methoxy‐3, 4‐dihydrocarbostyril, a Novel Matrix Metalloproteinase Inhibitor[J]. Japanese journal of cancer research, 1999, 90 (3) : 333-341.