PBRM1/SMARCA2,4-ligand-1
PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1 is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118[2].
Product Specifications
CAS Number
1997321-76-2
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC1=C(C=C(N=N1)C2=C(C=CC=C2)O)C3=CC=CC=C3
Molecular Formula
C16H13N3O
Molecular Weight
263.29
References & Citations
[1]Taylor, A. M., et al., (2022) . GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. Journal of medicinal chemistry, 65 (16), 11177–11186.|[2]Tongchen He, et al. Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer. bioRxiv [Preprint]. 2024 Mar 2:2024.02.29.582768.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Frequently Asked Questions
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