DAurAB2
DAurAB2 is a dual-degrading PROTAC that potently degrades Aurora-A and Aurora-B with DC50s of 59 nM and 39 nM, respectively. dAurAB2 reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells. dAurAB2 can be used for the study of neuroblastoma. (Pink, Aurora ligand ; Blue, E3 ligand: (HY-103597) ; Black, linker (HY-W105740) ).
Product Specifications
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Purity
98.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCCCCCCCCCCC(N1CCN(C2=CC=C(C3=NC4=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C4N3)C=C2)CC1)=O)COC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O
Molecular Formula
C52H62BrN11O8
Molecular Weight
1049.02
References & Citations
[1]Sydney E. Nelson, et al. Development of Dual Aurora-A and Aurora-B Degrading PROTACs for MYCN-Amplified Neuroblastoma. ChemMedChem. 20 November 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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