SK2187
SK2187 is a selective AURKA PROTAC degrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252) ; Blue: E3 ligand (HY-103597) ; Black: Linker: Amino-PEG3-alcohol (HY-W015088) ) [1].
Product Specifications
CAS Number
[3038446-91-9]
Product Name Alternative
JB301
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Purity
95.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=O)=C3C1=O
Molecular Formula
C45H49ClFN7O11S
Molecular Weight
950.43
References & Citations
[1]Muhammad Rishf, et al. Targeted AURKA degradation: Towards new therapeutic agents for neuroblastoma. Eur J Med Chem. 2023 Feb 5:247:115033.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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