BU72

BU72 is a highly potent and long-acting agonist of μ and κ opioid receptors, and also has a partial agonist effect on δ opioid receptors (EC50 values are 0.054, 0.033, and 0.58 nM, respectively) . BU72 has a strong and long-lasting analgesic effect, which is mainly mediated by μ opioid receptors. BU72 has a long-lasting activity and can partially reverse the analgesic effect of morphine. BU72 can be used in the study of opioid dependence[1].

Product Specifications

CAS Number

[173265-76-4]

UNSPSC

12352005

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CO[C@@]12[C@](N[C@@H]3C4=CC=CC=C4)([H])[C@@](C5=CC(O)=CC=C5C[C@@]6([H])N7C)(CC7)C6(C=C2)CC13C

Molecular Formula

C28H32N2O2

Molecular Weight

428.57

References & Citations

[1]Neilan CL, et al. Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist. Eur J Pharmacol. 2004 Sep 19;499 (1-2) :107-16.