Hsp90-IN-40

Hsp90-IN-40 (Compound 15b) is a heat shock protein 90 (Hsp90) C-terminal inhibitor. Hsp90-IN-40 exhibits antiproliferative activity against SKBr3 and MCF-7 breast cancer cells (IC50 of 2.57 µM and 2.43 µM, respectively) . Hsp90-IN-40 inhibits cancer cell growth by inhibiting the Hsp90 C-terminal function, leading to Hsp90-dependent protein degradation. Hsp90-IN-40 can be used in breast cancer research[1].

Product Specifications

CAS Number

[2169278-81-1]

UNSPSC

12352005

Target

HSP

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

COC1=C(C2=CC(OC)=CC=C2)C=C(C=C1)C(N[C@@H]3CC[C@H](C4=CC=C(C=C4)OC5CCN(CC5)C)CC3)=O

Molecular Formula

C33H40N2O4

Molecular Weight

528.68

References & Citations

[1]Garg G, et al. Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C-terminal Inhibitors. Chemistry. 2017 Nov 21;23 (65) :16574-16585.