DEDN6526A
DEDN6526A is an antibody-drug conjugate (ADC) consisting of the humanized anti-ETBR antibody DEDN6526A (RG-7636) (HY-P990573 conjugated with valine-citrulline (vc) and the tubulin inhibitor MMAE (McMMAF) (HY-15575) . DEDN6526A induces apoptosis and can be used in melanoma research[1].
Product Specifications
UNSPSC
12352203
Target
Antibody-Drug Conjugates (ADCs) ; Apoptosis; Endothelin Receptor; Microtubule/Tubulin
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
[DEDN6526A]
References & Citations
[1]Sandhu S, et al. Phase I study of the anti-endothelin B receptor antibody-drug conjugate DEDN6526A in patients with metastatic or unresectable cutaneous, mucosal, or uveal melanoma. Invest New Drugs. 2020 Jun;38 (3) :844-854.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
Phase 1
Curated Selection
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