G3-YSD
G3-YSD, a G3-ended Y-form short DNA, is a Cyclic GMP-AMP synthase (cGAS) agonist. G3-YSD is a minimal immunostimulatory DNA motif and activates the type I interferon-inducing DNA sensor cGAS in a structure-and sequence-dependent manner. G3-YSD can be used for the detection of HIV-1 ssDNA[1].
Product Specifications
CAS Number
[2780391-08-2]
UNSPSC
12352208
Target
Cyclic GMP-AMP Synthase; IFNAR
Related Pathways
Immunology/Inflammation
Field of Research
Infection
Smiles
[DNA,d(G-G-G-T-A-T-A-T-A-T-A-T-G-C-A-T-A-T-A-T-A-T-A-G-G-G)]
References & Citations
[1]Herzner AM, et al. Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat Immunol. 2015 Oct;16 (10) :1025-33.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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