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Puxitatug samrotecan

Puxitatug samrotecan (AZD8205) is an antibody-drug conjugate (ADC) targeting B7-H4. Puxitatug samrotecan is composed of the Puxitatug (HY-P990059) antibody targeting B7-H4, randomly conjugated to the Puxitatug samrotecan drug-linker (HY-163487) by reducing inter-chain cysteines. Puxitatug samrotecan has anti-tumor activity and can be used in the study of cancers expressing B7-H4[1].

Product Specifications

CAS Number

[2760250-80-2]

Product Name Alternative

AZD 8205

UNSPSC

12352203

Target

Antibody-Drug Conjugates (ADCs)

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.01

Smiles

[Puxitatugsamrotecan]

References & Citations

[1]Kinneer K, et al. Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305. Clin Cancer Res. 2023 Mar 14;29 (6) :1086-1101.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-171689/Puxitatug-samrotecan-SDS-MedChemExpress.pdf

Scientific Category

ADC Related

Clinical Information

Phase 2

Available Sizes

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