Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB carbonic acid
Mal-Cyclobutane-1,1-dicarboxamide-Cit-PAB carbonic acid is a PROTAC linker that can be used in the synthesis of L1BC8 (HY-164995) [1].
Product Specifications
UNSPSC
12352211
Target
PROTAC Linkers
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(O)OCC1=CC=C(NC([C@@H](NC(C2(CCC2)C(NCCCCCN3C(C=CC3=O)=O)=O)=O)CCCNC(N)=O)=O)C=C1
Molecular Formula
C29H38N6O9
Molecular Weight
614.65
References & Citations
[1]Dragovich PS, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64 (5) :2576-2607.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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