G721-0282

G721-0282 is an orally active CHI3L1 inhibitor. G721-0282 can reduce the expression of inflammatory proteins and cytokines. G721-0282 inhibits the activation of the NF-κB signaling pathway. G721-0282 inhibits neuroinflammation and reduces anxious behavior. G721-0282 significantly inhibits the proliferation of osteosarcoma (OS) cells by suppressing the STAT3 signaling pathway. G721-0282 induces OS cell apoptosis by upregulating pro-apoptotic protein levels and downregulating anti-apoptotic protein levels. G721-0282 can be used for researches on neuroinflammatory conditions and cancer[1][2].

Product Specifications

CAS Number

[946378-12-7]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; CDK; COX; ERK; Glycosidase; NF-κB; p38 MAPK; STAT; Survivin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Smiles

O=C1C2=C(C(CCCC)=CN=C2N(C)C(N1C)=O)SCC(NCC=C)=O

Molecular Formula

C18H24N4O3S

Molecular Weight

376.47

References & Citations

[1]Ham HJ, et al. G721-0282 Exerts Anxiolytic-Like Effects on Chronic Unpredictable Mild Stress in Mice Through Inhibition of Chitinase-3-Like 1-Mediated Neuroinflammation. Front Cell Neurosci. 2022 Mar 7;16:793835|[2]Park KR, et al. G721-0282 inhibits cell growth and induces apoptosis in human osteosarcoma through down-regulation of the STAT3 pathway. Int J Biol Sci. 2020 Jan 1;16 (2) :330-341.