RNAP-σ interaction inhibitor-2
RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor of RNA polymerase-sigma factors interaction. RNAP-σ interaction inhibitor-2 exhibits the activity against S. aureus with MIC values of 2 µg/mL[1].
Product Specifications
CAS Number
3077454-53-3
UNSPSC
12352101
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
O=C(C1=CC(C)=CC=C1N(S(=O)(C2=CC=C(C([N+]([O-])=O)=C2)SC3=CC=C(C(Cl)=C3)Cl)=O)CC4=CC(Cl)=CC=C4)O
Molecular Formula
C27H19Cl3N2O6S2
Molecular Weight
637.94
References & Citations
[1]Jiqing Ye, et al. Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria. Bioorg Chem. 2024 Feb:143:106983.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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