RNAP-σ interaction inhibitor-2

RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor of RNA polymerase-sigma factors interaction. RNAP-σ interaction inhibitor-2 exhibits the activity against S. aureus with MIC values of 2 µg/mL[1].

Product Specifications

CAS Number

[3077454-53-3]

UNSPSC

12352101

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

O=C(C1=CC(C)=CC=C1N(S(=O)(C2=CC=C(C([N+]([O-])=O)=C2)SC3=CC=C(C(Cl)=C3)Cl)=O)CC4=CC(Cl)=CC=C4)O

Molecular Formula

C27H19Cl3N2O6S2

Molecular Weight

637.94

References & Citations

[1]Jiqing Ye, et al. Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria. Bioorg Chem. 2024 Feb:143:106983.