RNAP-σ interaction inhibitor-1

RNAP-σ interaction inhibitor1 (compound 5d) is an inhibitor of RNA polymerase-sigma factors interaction. RNAP-σ interaction inhibitor-1 exhibits the activity against Streptococci with MIC values of 1-2 µg/mL[1].

Product Specifications

CAS Number

[2408055-45-6]

UNSPSC

12352101

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(C1=CC=C(C=C1NS(=O)(C2=CC=C(C([N+]([O-])=O)=C2)SC3=CC=C(C(Cl)=C3)Cl)=O)Cl)O

Molecular Formula

C19H11Cl3N2O6S2

Molecular Weight

533.79

References & Citations

[1]Jiqing Ye, et al. Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria. Bioorg Chem. 2024 Feb:143:106983.