RNAP-σ interaction inhibitor-1
RNAP-σ interaction inhibitor1 (compound 5d) is an inhibitor of RNA polymerase-sigma factors interaction. RNAP-σ interaction inhibitor-1 exhibits the activity against Streptococci with MIC values of 1-2 µg/mL[1].
Product Specifications
CAS Number
2408055-45-6
UNSPSC
12352101
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(C1=CC=C(C=C1NS(=O)(C2=CC=C(C([N+]([O-])=O)=C2)SC3=CC=C(C(Cl)=C3)Cl)=O)Cl)O
Molecular Formula
C19H11Cl3N2O6S2
Molecular Weight
533.79
References & Citations
[1]Jiqing Ye, et al. Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria. Bioorg Chem. 2024 Feb:143:106983.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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