DCEM1
DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction of HSP60 with ClpP, thereby blocking the mitochondrial unfolded protein response. DCEM1 inhibits β-catenin expression and ATP production in PC-3 and TKO cells. DCEM1 can be used in prostate cancer research[1][2].
Product Specifications
CAS Number
878949-21-4
UNSPSC
12352005
Target
HSP; β-catenin
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCOC1=CC(CNCC2=NC3=C(N2)C=CC=C3)=CC=C1OCC4=CC=CS4
Molecular Formula
C22H23N3O2S
Molecular Weight
393.50
References & Citations
[1]Dhyan C, et al. Methods for disrupting mitochondrial unfolded protein response. WO2022103897. WIPO (PCT) . 2021-11-10.|[2]Woytash JA, et al. Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer. Oncogene. 2025 Apr;44 (12) :820-834.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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