DCEM1
DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction of HSP60 with ClpP, thereby blocking the mitochondrial unfolded protein response. DCEM1 inhibits β-catenin expression and ATP production in PC-3 and TKO cells. DCEM1 can be used in prostate cancer research[1][2].
Product Specifications
CAS Number
[878949-21-4]
UNSPSC
12352005
Target
HSP; β-catenin
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCOC1=CC(CNCC2=NC3=C(N2)C=CC=C3)=CC=C1OCC4=CC=CS4
Molecular Formula
C22H23N3O2S
Molecular Weight
393.50
References & Citations
[1]Dhyan C, et al. Methods for disrupting mitochondrial unfolded protein response. WO2022103897. WIPO (PCT) . 2021-11-10.|[2]Woytash JA, et al. Mitochondrial unfolded protein response-dependent β-catenin signaling promotes neuroendocrine prostate cancer. Oncogene. 2025 Apr;44 (12) :820-834.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
36-1725-100 100 µg
Monoclonal Antibody to TGF-alphaalpha (Transforming Growth Factor alpha) (Clone : MF9)
Ask
View Details 
MBS6204783-01 0.1 mL
ENSA (Endosulfine alpha, OTTHUMP00000032931, OTTHUMP00000032932, OTTHUMP00000034001, OTTHUMP00000034003, OTTHUMP00000034004, OTTHUMP00000034005, OTTHUMP00000034006, MGC4319, MGC78563, MGC8394) (MaxLight 490)
Ask
View Details 
MBS6204783-02 5x 0.1 mL
ENSA (Endosulfine alpha, OTTHUMP00000032931, OTTHUMP00000032932, OTTHUMP00000034001, OTTHUMP00000034003, OTTHUMP00000034004, OTTHUMP00000034005, OTTHUMP00000034006, MGC4319, MGC78563, MGC8394) (MaxLight 490)
Ask
View Details