SIK2-IN-3
SIK2-IN-3 is an orally active SIK1/2 selective inhibitor (IC50: 0.128/0.084 μM) . SIK2-IN-3 inhibits CRTC3 phosphorylation and myeloid cell pro-inflammatory cytokine production. SIK2-IN-3 ameliorates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model[1].
Product Specifications
CAS Number
2810809-10-8
UNSPSC
12352005
Target
Salt-inducible Kinase (SIK)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
CN(C1)CC[C@H]1COC2=CN=C(C#N)C=C2C3=CC4=CC(NC(C5CC5)=O)=NN4C=C3
Molecular Formula
C23H24N6O2
Molecular Weight
416.48
References & Citations
[1]Babbe H, et al. Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proc Natl Acad Sci U S A. 2024 Jan 2;121 (1) :e2307086120.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIK1; SIK2
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