3′-Deoxy CTP

3′-Deoxy CTP is a nucleotide analogue and a mandatory chain terminator. 3′-Deoxy CTP can cause chain termination by lacking the 3′-hydroxyl group, inhibiting the RNA synthesis activity of HCV nonstructural protein (NS5B) polymerase and blocking viral replication. 3′-Deoxy CTP can be used to study the chain termination mechanism of HCV polymerase and the development of antiviral drugs[1].

Product Specifications

CAS Number

[69383-05-7]

UNSPSC

12352005

Target

HCV

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O[C@@H]1C[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O[C@H]1N2C(N=C(N)C=C2)=O

Molecular Formula

C9H16N3O13P3

Molecular Weight

467.16

References & Citations

[1]Deval J, et al. Pyrophosphorolytic excision of nonobligate chain terminators by hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother. 2007 Aug;51 (8) :2920-8.