3′-Azido-2′,3′-dideoxy-CTP

3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analog containing a 3-azido group. As a chain terminator, 3′-Azido-2′,3′-dideoxy-CTP can be incorporated into the nascent DNA chain by HIV reverse transcriptase. 3′-Azido-2′,3′-dideoxy-CTP terminates DNA synthesis due to the lack of a 3'-hydroxyl group, thereby inhibiting viral replication. 3′-Azido-2′,3′-dideoxy-CTP has IC50 values of 15.6 μM and 160.8 μM for WT HIV and AZTR HIV. 3′-Azido-2′,3′-dideoxy-CTP has antiviral activity[1].

Product Specifications

CAS Number

[92562-77-1]

Product Name Alternative

AZddCTP

UNSPSC

12352208

Target

DNA/RNA Synthesis; HIV

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)C[C@@H]1N=[N+]=[N-]

Molecular Formula

C9H15N6O12P3

Molecular Weight

492.17

References & Citations

[1]Sluis-Cremer N, et al. The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. J Biol Chem. 2005 Aug 12;280 (32) :29047-52.