3′-Azido-2′,3′-dideoxy-GTP
3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a Ki value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro[1].
Product Specifications
CAS Number
94059-38-8
Product Name Alternative
AZddGTP
UNSPSC
12352208
Target
Telomerase
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Smiles
O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N=C(N)N3)=O)C[C@@H]1N=[N+]=[N-]
Molecular Formula
C10H15N8O12P3
Molecular Weight
532.19
References & Citations
[1]Liu X, et al. 3'-Azido-2',3'-dideoxynucleoside 5'-triphosphates inhibit telomerase activity in vitro, and the corresponding nucleosides cause telomere shortening in human HL60 cells. Nucleic Acids Res. 2007;35 (21) :7140-9.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
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