3′-Azido-2′,3′-dideoxy-GTP

3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective telomerase inhibitor with a Ki value of 1.5 μM. 3′-Azido-2′,3′-dideoxy-GTP can be incorporated into the 3′-terminus of DNA by telomerase. 3′-Azido-2′,3′-dideoxy-GTP inhibits telomerase activity in HeLa cells in vitro[1].

Product Specifications

CAS Number

[94059-38-8]

Product Name Alternative

AZddGTP

UNSPSC

12352208

Target

Telomerase

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Smiles

O=P(OP(OP(O)(O)=O)(O)=O)(O)OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N=C(N)N3)=O)C[C@@H]1N=[N+]=[N-]

Molecular Formula

C10H15N8O12P3

Molecular Weight

532.19

References & Citations

[1]Liu X, et al. 3'-Azido-2',3'-dideoxynucleoside 5'-triphosphates inhibit telomerase activity in vitro, and the corresponding nucleosides cause telomere shortening in human HL60 cells. Nucleic Acids Res. 2007;35 (21) :7140-9.