Mal-N (Me) -C6-N (Me) -PNU-159682
Mal-N (Me) -C6-N (Me) -PNU-159682 (Compound 27), an agent-linker conjugate for ADC, consists the ADC linker Mal-N (Me) -C6-N (Me) and a potent ADC cytotoxin PNU-159682. Mal-N (Me) -C6-N (Me) -PNU-159682 (Compound 27) selectively delivers the payload to CD46-expressing cells, where the linker is cleaved by cathepsin B to release PNU-159682, inducing DNA damage and apoptosis. Mal-N (Me) -C6-N (Me) -PNU-159682 shows durable tumor regression in xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) [1].
Product Specifications
CAS Number
2682939-57-5
UNSPSC
12352203
Target
Apoptosis; Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis
Field of Research
Cancer
Smiles
Molecular Formula
C47H56N4O17
Molecular Weight
948.96
References & Citations
[1]Holte D, et al. Evaluation of PNU-159682 antibody drug conjugates (ADCs) . Bioorg Med Chem Lett. 2020 Dec 15;30 (24) :127640.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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