Mal-N (Me) -C6-N (Me) -PNU-159682

Mal-N (Me) -C6-N (Me) -PNU-159682 (Compound 27), an agent-linker conjugate for ADC, consists the ADC linker Mal-N (Me) -C6-N (Me) and a potent ADC cytotoxin PNU-159682. Mal-N (Me) -C6-N (Me) -PNU-159682 (Compound 27) selectively delivers the payload to CD46-expressing cells, where the linker is cleaved by cathepsin B to release PNU-159682, inducing DNA damage and apoptosis. Mal-N (Me) -C6-N (Me) -PNU-159682 shows durable tumor regression in xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) [1].

Product Specifications

CAS Number

[2682939-57-5]

UNSPSC

12352203

Target

Apoptosis; Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis

Field of Research

Cancer

Smiles

OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@]6([H])N7[C@]([C@H](OCC7)OC)([H])O[C@]6([H])[C@@H](O5)C)=C1C[C@](O)(C4)C(COC(N(C)CCCCCCN(C)C(CN8C(C=CC8=O)=O)=O)=O)=O