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Cenersen

Cenersen (EL625) is an oligonucleotide targeting TP53. Cenersen can eliminate the activity of TP53 gain-of-function mutants and increase the sensitivity of lymphoma cells to cytotoxic chemotherapy in vitro. Cenersen can be used for the study of chronic lymphocytic leukemia (CLL) [1].

Product Specifications

CAS Number

872847-66-0

Product Name Alternative

EL625

UNSPSC

12352211

Target

MDM-2/p53

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

95.07

Smiles

[Cenersen]

References & Citations

[1]Lanasa MC, et al. Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia. Leuk Lymphoma. 2012 Feb;53 (2) :218-24.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Oligonucleotides

Clinical Information

Phase 2

Frequently Asked Questions

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