Thio-acridone
Thio-acridone (SACD) is a photosensitizer (HAF-PSs) . Thio-acridone forms a long-lived triplet state upon excitation by 470 nm visible light, , ultimately generating singlet oxygen to damage the structures and functions of target cells such as cancer cells. Thio-acridone is promising for research of cancers[1]. Thio-acridone is a CDK4/Cyclin D1 inhibitor (IC50 = 2 uM) [2].
Product Specifications
CAS Number
6540-78-9
Product Name Alternative
SACD
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
S=C1C2=C(NC3=C1C=CC=C3)C=CC=C2
Molecular Formula
C13H9NS
Molecular Weight
211.28
References & Citations
[1]Acquah C, et al. Electronic relaxation pathways in thio-acridone and thio-coumarin: two heavy-atom-free photosensitizers absorbing visible light. Phys Chem Chem Phys. 2024 Nov 27;26 (46) :28980-28991.|[2]Kubo A, Nakagawa K, Varma RK, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999;5 (12) :4279-4286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4
Frequently Asked Questions
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