Metahexestrol

Metahexestrol is an estrogen receptor (E2R) inhibitor with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cells (ED50 = 1.0 μM) . Additionally, Metahexestrol also exhibits inhibitory effects in estrogen receptor-negative MDA-MB-231 cells, and its antiproliferative activity cannot be reversed by estrogen, suggesting that its mechanism of action may be partially independent of the E2R pathway. Metahexestrol can be used in research on estrogen-dependent breast cancer[1].

Product Specifications

CAS Number

[71953-72-5]

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

CC[C@H](C1=CC(O)=CC=C1)[C@H](C2=CC(O)=CC=C2)CC

Molecular Formula

C18H22O2

Molecular Weight

270.37

References & Citations

[1]Hartmann R W, et al. Anti-proliferative effects of 1, 2-diphenylethane oestrogens and anti-oestrogens on human breast cancer cells[J]. Journal of cancer research and clinical oncology, 1985, 110 (1) : 17-24.