SKF 10810
SKF 10810 is a GABAA receptor antagonist with an EC50 of 4.3 μM. By blocking GABAergic inhibition of the brain's reward pathways, SKF 10810 may exert antidepressant effects. SKF 10810 can be used for research in neurological disorders[1].
Product Specifications
CAS Number
[22196-65-2]
UNSPSC
12352005
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC(C1=CC(C(CCCN(C)C)C2=C(C=CC=C2)O3)=C3C=C1)(F)F
Molecular Formula
C19H20F3NO
Molecular Weight
335.36
References & Citations
[1]Squires RF, et al. Antidepressants and metabolites that block GABAA receptors coupled to 35S-t-butylbicyclophosphorothionate binding sites in rat brain. Brain Res. 1988 Feb 16;441 (1-2) :15-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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