SKP-451

SKP-451 is an ATP-sensitive potassium (K+) channel agonist. SKP-451 activates the ATP-sensitive K+ channels, promotes the efflux of K+, causes membrane hyperpolarization, and inhibits the influx of Ca2+, thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR) . SKP-451 is promising for research of cardiovascular diseases[1].

Product Specifications

CAS Number

[181137-41-7]

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Smiles

[O-][N+](C1=CC=C2O[C@](C)(C3OCCO3)C=C(N4C(CCC4)=O)C2=C1)=O

Molecular Formula

C17H18N2O6

Molecular Weight

346.33

References & Citations

[1]Hong KW, et al. Pharmacological profiles of SKP-450 and its family, a K+ channel opener, in comparison with levcromakalim. Pharmacol Res. 1998 Sep;38 (3) :191-7.