SMW139

SMW139 is a selective allosteric antagonist of P2X7 receptor, with a Ki value of 32 nM for human P2X7R. The half-life of SMW139 in rat liver microsomes is 47 minutes. SMW139 can be used for inflammation, Alzheimer’s disease, multiple sclerosis study[1].

Product Specifications

CAS Number

[2133010-38-3]

UNSPSC

12352005

Target

Interleukin Related; P2X Receptor

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=CC(OC)=CC=C1Cl)NCC(C[C@]2(C3)F)(C[C@@]43F)C[C@](C4)(C2)F

Molecular Formula

C19H21ClF3NO2

Molecular Weight

387.82

References & Citations

[1]Janssen B, et al. Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation. Sci Rep. 2018 Apr 26;8 (1) :6580.