SMW139
SMW139 is a selective allosteric antagonist of P2X7 receptor, with a Ki value of 32 nM for human P2X7R. The half-life of SMW139 in rat liver microsomes is 47 minutes. SMW139 can be used for inflammation, Alzheimer’s disease, multiple sclerosis study[1].
Product Specifications
CAS Number
2133010-38-3
UNSPSC
12352005
Target
Interleukin Related; P2X Receptor
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CC(OC)=CC=C1Cl)NCC(C[C@]2(C3)F)(C[C@@]43F)C[C@](C4)(C2)F
Molecular Formula
C19H21ClF3NO2
Molecular Weight
387.82
References & Citations
[1]Janssen B, et al. Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation. Sci Rep. 2018 Apr 26;8 (1) :6580.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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