CGS 24592

CGS 24592 is an orally active, selective and potent neutral endopeptidase 24.11 (NEP) inhibitor with an IC50 value of 1.6 nmol/L. CGS 24592 reduces the degradation of atrial natriuretic peptide (ANP), increases the concentration of ANP in the plasma, and reduces blood pressure. CGS 24592 is promising for research of cardiovascular disease, such as hypertension and congestive heart failure[1].

Product Specifications

CAS Number

[147923-04-4]

UNSPSC

12352211

Target

Prolyl Endopeptidase (PREP)

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

OC(CCNC([C@@H](NCP(O)(O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O)=O

Molecular Formula

C19H23N2O6P

Molecular Weight

406.37

References & Citations

[1]Trapani AJ, et al. The pharmacology of CGS 25462: a potent, orally bioavailable, long-acting inhibitor of neutral endopeptidase 24.11. J Hypertens Suppl. 1993 Dec;11 (5) :S220-1.