LEQ803
LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib (HY-15777), which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology[1].
Product Specifications
CAS Number
[1211441-59-6]
Product Name Alternative
N-Desmethyl Ribociclib
UNSPSC
12352005
Target
Cytochrome P450; Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
99.37
Solubility
DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC2=C(N1C3CCCC3)N=C(NC4=NC=C(N5CCNCC5)C=C4)N=C2)NC
Molecular Formula
C22H28N8O
Molecular Weight
420.51
References & Citations
[1]James AD, et al. An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data. Pharmacol Res Perspect. 2020 Jun;8 (3) :e00599.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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