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LEQ803

LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib , which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology[1].

Product Specifications

CAS Number

1211441-59-6

Product Name Alternative

N-Desmethyl Ribociclib

UNSPSC

12352005

Target

Cytochrome P450; Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

99.37

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC2=C(N1C3CCCC3)N=C(NC4=NC=C(N5CCNCC5)C=C4)N=C2)NC

Molecular Formula

C22H28N8O

Molecular Weight

420.51

References & Citations

[1]James AD, et al. An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data. Pharmacol Res Perspect. 2020 Jun;8 (3) :e00599.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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