WR-27653

WR-27653 (RC-12) is a derivative of Catechol with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi-rhesus monkey (Macaca mulatta) model. WR-27653 has antimalarial activity[1][2].

Product Specifications

CAS Number

[6042-36-0]

Product Name Alternative

RC-12

UNSPSC

12352101

Target

Drug Derivative; Parasite

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

BrC1=C(N(CCN(CC)CC)CCN(CC)CC)C=C(OC)C(OC)=C1

Molecular Formula

C20H36BrN3O2

Molecular Weight

430.42

References & Citations

[1]Werbel LM, et al. Synthesis and physical properties of the antimalarial agent 4- (2-bromo-4,5-dimethoxyphenyl) -1,1,7,7-tetraethyldiethylenetriamine (RC-12) (WR-27,653) . J Pharm Sci. 1967 Oct;56 (10) :1335-7. |[2]Dong Y, et al. Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12) . ACS Omega. 2022 Mar 30;7 (14) :12401-12411.