LPT99
LPT-99 is an antagonist of apoptotic protease activating factor 1 (APAF-1). LPT-99 suppresses the activation of procaspase-9. LPT99 suppresses Cisplatin -induced apoptosis. LPT99 can effectively mitigate cisplatin-induced hearing loss in rats.[1]
Product Specifications
CAS Number
1263477-83-3
UNSPSC
12352005
Target
Apoptosis; Caspase
Related Pathways
Apoptosis
Field of Research
Others
Smiles
O=C(CC1C(N(CCC2=CC=C(C=C2Cl)Cl)CC(N1CCC3=CC=CS3)=O)=O)NCCC4=CNC5=C4C=C(OC)C=C5
Molecular Formula
C31H32Cl2N4O4S
Molecular Weight
627.58
References & Citations
[1]Murillo-Cuesta S, et al. Therapeutic efficiency of the APAF-1 antagonist LPT99 in a rat model of cisplatin-induced hearing loss. Clin Transl Med. 2021 Apr;11 (4) :e363.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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