TAK-075
TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. TAK-075 can stimulate the transient secretion of parathyroid hormone (PTH) in rats and can effectively prevent a significant reduction in PTH secretion caused by the accumulation of active metabolites, maintaining the normal secretion pattern of PTH. TAK-075 can be used in the research of metabolic diseases and osteoporosis[1].
Product Specifications
CAS Number
[667931-33-1]
UNSPSC
12352005
Target
CaSR
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.CCC(CC)(C2=CC=C(C=C2)CC)NC(C3=C4N(N=C3C)C(C)(C[C@H](C5=CC=CC=C5)N4)C)=O
Molecular Formula
C36H46N4O4S
Molecular Weight
630.84
References & Citations
[1]Castoreno AB, et al. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6 (6) :457-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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