GSM III
GSM III is a γ-Secretase complexe (GSEC) modulator. GSM III significantly regulates amyloid-β (Aβ) length at the extracellular interface between the protease (NCT, PSEN) and the substrate APPC99. GSM III can be used for Alzheimer's disease (AD) research[1].
Product Specifications
CAS Number
[1493797-28-6]
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(N2C[C@@H](C)N1CC3=CN(C)C4=C3C=C(C(F)(F)F)C=C4)=CC=C(N5C=C(C)N=C5)C2=O
Molecular Formula
C24H22F3N5O2
Molecular Weight
469.46
References & Citations
[1]Petit D, et al. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators. EMBO J. 2019 Jun 17;38 (12) :e101494.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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