GSM III

GSM III is a γ-Secretase complexe (GSEC) modulator. GSM III significantly regulates amyloid-β (Aβ) length at the extracellular interface between the protease (NCT, PSEN) and the substrate APPC99. GSM III can be used for Alzheimer's disease (AD) research[1].

Product Specifications

CAS Number

[1493797-28-6]

UNSPSC

12352005

Target

Amyloid-β; γ-secretase

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(N2C[C@@H](C)N1CC3=CN(C)C4=C3C=C(C(F)(F)F)C=C4)=CC=C(N5C=C(C)N=C5)C2=O

Molecular Formula

C24H22F3N5O2

Molecular Weight

469.46

References & Citations

[1]Petit D, et al. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators. EMBO J. 2019 Jun 17;38 (12) :e101494.