Lyso-Monosialoganglioside GM3
Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analogue of Ganglioside GM3 (HY-114456) with antitumor activities. Lyso-Monosialoganglioside inhibits EGF-induced increases in EGFR kinase activity in A431 epithelial cancer cells[1].
Product Specifications
CAS Number
[94458-63-6]
Product Name Alternative
Lyso-GM3
UNSPSC
12352005
Target
Drug Derivative; EGFR
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC)CO)O)=O
Molecular Formula
C41H74N2O20
Molecular Weight
915.03
References & Citations
[1]Li T, et al. Chemoenzymatic synthesis and biological evaluation of ganglioside GM3 and lyso-GM3 as potential agents for cancer therapy. Carbohydr Res. 2021 Nov;509:108431.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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